2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112597
    Mavodelpar free acid 942594-93-6 98%
    Mavodelpar free acid is a PPARδ agonist extracted from patent US20180071304, compound example 10. Mavodelpar (free acid) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mavodelpar free acid
  • HY-112690
    Pradefovir 625095-60-5 98%
    Pradefovir is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM.
    Pradefovir
  • HY-112828
    LEI105 1800327-36-9 98%
    LEI105 is a potent, highly selective and reversible dual diacylglycerol lipase (DAGL)-α/DAGL-β inhibitor. LEI105 reduces 2-arachidonoylglycerol levels in Neuro2A cells. LEI105 also reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model. LEI105 is promising for research of diseases, such as obesity, related metabolic disorders and neuroinflammation.
    LEI105
  • HY-112851
    Diacylglycerol acyltransferase inhibitor-1 1610800-25-3 98%
    Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor.
    Diacylglycerol acyltransferase inhibitor-1
  • HY-113045
    Aquacobalamin 13422-52-1 98%
    Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO5- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant.
    Aquacobalamin
  • HY-113112
    8,9-DiHETrE 192461-96-4 98%
    8,9-DiHETrE is an ester product.
    8,9-DiHETrE
  • HY-113113
    13,14-Dihydro PGE1 19313-28-1 98%
    13,14-Dihydro PGE1 is a metabolite of PGE1 (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID50 = 10.8 ng/mL platelet rich plasma).
    13,14-Dihydro PGE1
  • HY-113132
    5,6-DHET 213382-49-1 98%
    5,6-DHET is an ester product.
    5,6-DHET
  • HY-113169
    Estriol 3-glucuronide 2479-91-6 98%
    Estriol-3-glucuronide exists in amniotic fluid during normal pregnancy and occurs naturally in urine.
    Estriol 3-glucuronide
  • HY-113243
    1-Oleoyl lysophosphatidylcholine 3542-29-8 98%
    1-Oleoyl lysophosphatidylcholine is a GPR119 activator and insulin secretion potentiator with a human GPR119 EC50 of 1.5 μM.1-Oleoyl lysophosphatidylcholine acts as a bioactive lipid mediator with diverse physiological and pathological functions.1-Oleoyl lysophosphatidylcholine can be used for the research of diabetes.
    1-Oleoyl lysophosphatidylcholine
  • HY-113274
    Pi-Methylimidazoleacetic acid 4200-48-0 98%
    Pi-Methylimidazoleacetic acid is a potential neurotoxin.
    Pi-Methylimidazoleacetic acid
  • HY-113288
    Campestanol 474-60-2 99.0%
    Campestanol is a phytosterol that can be found in plant food. Campestanol lowers serum cholesterol and low-density lipoprotein. Campestanol can be used for the research of metabolic disorders.
    Campestanol
  • HY-113293
    Estrone sulfate 481-97-0 98%
    Estrone sulfate is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate is also a substrate of the OATP1B3 transporter. Estrone sulfate can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate is applicable to breast cancer-related research.
    Estrone sulfate
  • HY-113359
    Uridine 5'-diphosphate 58-98-0 98%
    Uridine 5'-diphosphate (UDP) is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
    Uridine 5'-diphosphate
  • HY-113419
    Cer (d18:1/23:0) 67605-84-9 98%
    Cer (d18:1/23:0) is a ceramide (sphingolipid). The level of Cer (d18:1/23:0) increases in coronary heart disease patients exposed to Metformin. The level of Cer (d18:1/23:0) is elevated in Chinese prediabetic and type 2 diabetic patients, and positively correlates with fasting blood glucose levels. Cer (d18:1/23:0) can be used in studies related to coronary heart disease, prediabetes and type 2 diabetes.
    Cer (d18:1/23:0)
  • HY-113443
    12(S)-HPETE 71774-10-2 98%
    12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension.
    12(S)-HPETE
  • HY-113507
    PC(O-16:0/18:2(9Z,12Z)) 88542-95-4 98%
    PC(O-16:0/18:2(9Z,12Z)) is a phospholipid. PC(O-16:0/18:2(9Z,12Z)) serves as a substrate for Phospholipase A2.
    PC(O-16:0/18:2(9Z,12Z))
  • HY-113519
    14R(15S)-EET 98103-48-1 98%
    14R(15S)-EET (14R(15S)-EpETrE) is an oxylipin and a metabolite of Arachidonic acid (HY-109590).
    14R(15S)-EET
  • HY-113581
    Levemopamil 101238-51-1 98%
    Levemopamil is a calcium channel blocker and 5-HT2 receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure.
    Levemopamil
  • HY-113626
    (-)-Cyclopenin 20007-87-8 98%
    (-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective acetylcholinesterase (AChE) inhibitor with the IC50 of 2.04 μM.
    (-)-Cyclopenin
Cat. No. Product Name / Synonyms Application Reactivity